James Mishreki, once a professional poker player, has transformed his personal struggle with acne into a thriving business, Skin + Me. The dermatology service, which offers prescription-grade skincare subscriptions, has achieved remarkable success, generating nearly £40 million in revenue since its launch in 2020. Mishreki’s journey highlights a unique approach to entrepreneurship, focusing on customer needs and overcoming significant challenges.
Key Takeaways
- James Mishreki founded Skin + Me after experiencing debilitating acne in his youth and again in his twenties.
- The company offers personalised, prescription-grade skincare treatments via a subscription model.
- Skin + Me has achieved substantial financial success, with revenues nearing £40 million.
- Mishreki emphasizes the importance of "rejection training" and continuous improvement in entrepreneurship.
The Genesis of Skin + Me
Mishreki’s personal battle with acne, which began in his teenage years in Northumberland and recurred in his twenties, fueled his desire to address the widespread dissatisfaction within the £140 billion skincare industry. He observed that many individuals struggled to access regular consultations with dermatologists. This insight, coupled with his prior experience in tech startups, led him to co-found Skin + Me in 2018 with Philip Wilkinson.
From Poker to Personalised Skincare
Before venturing into health tech, Mishreki spent two years playing poker professionally after completing his marketing studies. He then co-founded Competitive Monitor, a retail intelligence firm, before pivoting to the e-commerce sector. An earlier venture, Mr & Mrs Oliver, a personalised skincare recommendation service, helped the founders understand consumer desires, particularly the value placed on expert consultations.
Building a Trusted Brand
Despite an initial flawed business model involving third-party products, the core idea of a personalised regime persisted. Skin + Me focused on building a regulatory-approved pharmacy, developing sophisticated personalisation technology, and cultivating a brand that consumers could trust. This involved extensive outreach to dermatologists and a commitment to using real community members in their marketing.
Navigating Investment and Growth
Mishreki advocates for "rejection training," viewing setbacks as learning opportunities. After an initial pursuit for smaller investment, the team successfully secured £8 million in seed funding to facilitate scaling. The company, which started with 20 employees, now boasts over 150 and has reportedly been valued at £160 million. Mishreki has since transitioned from CEO to chairman, remaining a key shareholder, and has launched another successful venture, Life Supplies, a refillable oral care brand.
Leadership and Future Outlook
Mishreki stresses the importance of setting high standards from the outset, particularly in early hires. He advises entrepreneurs to maintain a "paranoid" mindset, constantly seeking ways to improve customer experience, drawing inspiration from Andy Grove’s "Only the Paranoid Survive." While acknowledging the role of AI in business efficiency, he believes human interaction remains paramount for customer value.
Sources
- ‘Acne was debilitating for me so I set up a £40m business to help others’, Yahoo Finance UK.

